Endocrine Abstracts

Biotin is used in many hormone immunoassays as an immobilizing system as streptavidin binds biotin with high affinity. Recently, cases with spurious results from biotin interference have been increasing due to widespread use of vitamin supplements containing biotin. We report two cases of erroneously high total T3 levels caused by biotin interference.Case 1: A 88-year-old female who had total thyroidectomy for papillary thyroid cancer 10 years ago and ha...

Background: We evaluated the impact of the multifocality on post-lobectomy recurrence in patients with differentiated thyroid cancer (DTC).Methods: We analyzed 1,684 patients with DTC who underwent thyroid lobectomy from 2008 to 2015 using logistic regression models to calculate the relative risk on post-lobectomy recurrence.Results: Tumor diameter increased from 4.9 mm to 8.1 mm and the proportion of extrathyroidal extension (ETE)...

Background: The optimal initial surgical extent for medullary thyroid carcinoma (MTC) remains controversial. Aim of this study was to evaluate the ability of serum calcitonin and carcinoembryonic antigen(CEA) to predict the extent of surgery needed in the lateral neck in patients with MTC.Methods: This retrospective multicenter cohort study included data from patients with MTC surgically treated in the 6 tertiary medical centers in Korea from 1996 to 202...